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Niacin
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===As a dietary supplement=== In the United States, niacin is sold as a non-prescription dietary supplement with a range of 100 to 1000 mg per serving. These products often have a Structure/Function health claim<ref name=SFclaim>{{cite web |url=https://www.fda.gov/food/food-labeling-nutrition/structurefunction-claims |title=Structure/Function Claims |date=December 2017 |website=U.S. Food & Drug Administration |access-date=30 June 2020 |archive-date=10 June 2020 |archive-url=https://web.archive.org/web/20200610032745/https://www.fda.gov/food/food-labeling-nutrition/structurefunction-claims |url-status=live }}</ref> allowed by the US Food & Drug Administration (FDA). An example would be "Supports a healthy blood lipid profile." The American Heart Association strongly advises against the substitution of dietary supplement niacin for prescription niacin because of potentially serious side effects, which means that niacin should only be used under the supervision of a health care professional, and because manufacture of dietary supplement niacin is not as well-regulated by the FDA as prescription niacin.<ref name=AHA>{{cite web |url=https://www.heart.org/en/health-topics/cholesterol/prevention-and-treatment-of-high-cholesterol-hyperlipidemia/cholesterol-medications |title=Cholesterol Medications |date=10 November 2018 |website=American Heart Association |access-date=8 May 2020 |archive-date=5 April 2020 |archive-url=https://web.archive.org/web/20200405090134/https://www.heart.org/en/health-topics/cholesterol/prevention-and-treatment-of-high-cholesterol-hyperlipidemia/cholesterol-medications |url-status=live }}</ref> More than 30 mg niacin consumed as a dietary supplement can cause skin flushing. Face, arms and chest skin turns a reddish color because of vasodilation of small subcutaneous blood vessels, accompanied by sensations of heat, tingling and itching. These signs and symptoms are typically transient, lasting minutes to hours; they are considered unpleasant rather than toxic.<ref name="NIH Fact Sheet" />
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