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===Contraindications=== Prescription immediate release (Niacor) and extended release (Niaspan) niacin are [[contraindicated]] for people with either active or a history of [[liver disease]] because both, but especially Niaspan, have been associated with instances of serious, on occasion fatal, liver failure.<ref name=Niaspan /><ref name="ReferenceB"/> Both products are contraindicated for people with existing [[peptic ulcer disease]], or other bleeding problems because niacin lowers platelet count and interferes with blood clotting.<ref name=DailyMed /><ref name=Niaspan /><ref name="ReferenceB"/> Both products are also contraindicated for women who are pregnant or expecting to become pregnant because safety during pregnancy has not been evaluated in human trials. These products are contraindicated for women who are lactating because it is known that niacin is excreted into human milk, but the amount and potential for adverse effects in the nursing infant are not known. Women are advised to either not nurse their child or discontinue the drug. High-dose niacin has not been tested or approved for use in children under 16 years.<ref name=DailyMed /><ref name=Niaspan /><ref name="ReferenceB">{{cite web | title=Niaspan- niacin tablet, film coated, extended release | website=DailyMed | date=20 August 2013 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0dd18020-c211-423d-b3d8-a926ae626e14 | access-date=14 November 2022 | archive-date=14 November 2022 | archive-url=https://web.archive.org/web/20221114011459/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0dd18020-c211-423d-b3d8-a926ae626e14 | url-status=live }}</ref>
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